Q-omics provides the consensus-scored SEC11B profile across patient tissues and cancer cell-line models. SEC11B expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SEC11B is differentially expressed in 4, with the highest sampling consensus in COAD. Additionally, SEC11B RNA expression shows 7,703 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRP, COAD, and ACC as cancer lineages where SEC11B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SEC11B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SEC11B survival associations across molecular data types. SEC11B RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SEC11B RNA expression–survival associations across cancer types. High SEC11B expression shows unfavorable associations in KIRP and ACC, but favorable associations in BLCA, LUSC, SKCM and LUAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SEC11B RNA expression.
This table summarizes SEC11B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for SEC11B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SEC11B shows lower tumor expression in KIRC and higher tumor expression in COAD, HNSC and BLCA. The COAD box plot shows higher SEC11B RNA expression in tumor versus normal tissue (log2 FC = +0.628, t-test p < 0.001).
This table shows molecular features associated with SEC11B in patient tissues and cancer cell lines. In patient samples, SEC11B shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
