Across TCGA pan-cancer cohorts, SEC11B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SEC11B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SEC11B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC11B is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where SEC11B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC11B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.628	<.001	7	view →
HNSC	All	All	+0.074	.013	6	view →
KIRC	Male	III,IV	−0.089	.019	3	view →
BLCA	Male	III,IV	+0.198	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SEC11B RNA expression & survival · all SEC11B data types