Across TCGA pan-cancer cohorts, SEC11B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SEC11B data layer.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SEC11B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC11B expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUSC show a favorable association.
KIRP, BLCA, and ACC are the cancer types where SEC11B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.