SCX

Across TCGA patient cohorts, SCX mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCX-associated genes across cancer lineages are XKRY2, VCY1B, and RNA5SP205. Each is linked with SCX in more than 1 cancer types. Because this analysis shows association rather than direction, both SCX-to-partner and partner-to-SCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XKRY2 grouped by SCX-low versus SCX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCX→partner) and Y-score (partner→SCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	XKRY2 →	+0.019	+7.924	<.001	.008	3	1
UCEC	VCY1B →	+0.103	+7.060	<.001	<.001	3	1
UCEC	RNA5SP205 →	+0.447	+4.852	<.001	.006	3	1
UCEC	RNU6-391P →	+0.537	+5.027	<.001	.004	3	1
UCEC	MIR629 →	+0.646	+5.582	<.001	.002	3	1
UCEC	MIR1284 →	+0.450	+4.551	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

XKRY2 by SCX expression — LUSC

Explore this box plot interactively →