SCX

Across TCGA pan-cancer cohorts, SCX RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SCX data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SCX RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCX expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

KIRC, UVM, and ACC are the cancer types where SCX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.541	0.702	<.001	175	view →
UVM	DFS	Tertile	II,III,IV	0.338	0.806	<.001	121	view →
ACC	OS	Tertile	All	0.634	0.947	<.001	63	view →
UCEC	OS	Quartile	All	0.821	0.914	.008	44	view →
LGG	DFS	Median	All	0.641	0.841	<.001	39	view →
CESC	DFS	Tertile	All	0.742	0.893	<.001	32	view →
BLCA	OS	Median	II,III,IV	0.662	0.548	.006	29	view →
PAAD	DFS	Tertile	All	0.443	0.182	.002	26	view →
BRCA	DFS	Median	III,IV	0.726	0.856	.005	26	view →
STAD	OS	Median	III,IV	0.753	0.518	.010	24	view →
OV	OS	Median	IV	0.278	0.492	.011	22	view →
LUAD	DFS	Tertile	IV	0.238	0.896	.006	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SCX–KIRC (DFS)

Open the KIRC breakdown →