SCNN1B

Across TCGA cell cohorts, SCNN1B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCNN1B-associated genes across cancer lineages are NCR2, RAI2, and HCN4. Each is linked with SCNN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNN1B-to-partner and partner-to-SCNN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCR2 grouped by SCNN1B-low versus SCNN1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1B→partner) and Y-score (partner→SCNN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NCR2 →	+0.012	+4.437	<.001	.004	3	1
BLOOD_Leukemia	RAI2 →	+0.105	+4.428	<.001	.001	3	1
BLOOD_Leukemia	HCN4 →	+0.033	+3.855	.006	.007	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.042	+3.115	.004	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
OVARY	DEFA5 →	+0.105	+4.990	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

NCR2 by SCNN1B expression — SKIN

Explore this box plot interactively →