SCNN1B

Across TCGA pan-cancer cohorts, SCNN1B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SCNN1B data layer compared with 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SCNN1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated SCNN1B expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, LGG, and HNSC are the cancer types where SCNN1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.820	0.603	<.001	68	view →
LGG	OS	Median	All	0.346	0.550	<.001	54	view →
HNSC	DFS	Median	III,IV	0.721	0.599	.007	37	view →
CESC	OS	Median	All	0.862	0.730	.002	18	view →
KIRC	DFS	Median	All	0.758	0.847	.006	17	view →
LUSC	OS	Median	IV	0.255	0.851	.021	12	view →
LAML	DFS	Median	All	0.456	0.289	.031	12	view →
SKCM	DFS	Quartile	All	0.690	0.566	.007	11	view →
ACC	OS	Quartile	All	0.590	0.897	.023	11	view →
BLCA	OS	Median	II,III,IV	0.747	0.669	.019	9	view →
COAD	OS	Quartile	IV	0.787	0.321	.010	8	view →
LIHC	OS	Median	II,III,IV	0.524	0.703	.028	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SCNN1B–LUAD (OS)

Open the LUAD breakdown →