SCNN1B

Across TCGA pan-cancer cohorts, SCNN1B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SCNN1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCNN1B RNA is repressed in tumor relative to normal tissue. In most cancer types SCNN1B is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where SCNN1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCNN1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−4.958	<.001	12	view →
HNSC	Female	IV	−3.618	<.001	12	view →
KIRP	Male	All	−6.091	<.001	11	view →
KICH	Male	II,III,IV	−6.074	<.001	11	view →
COAD	Female	III,IV	−4.593	<.001	11	view →
THCA	Male	III,IV	−2.218	<.001	10	view →
LUAD	Male	II,III,IV	−2.184	<.001	9	view →
LIHC	All	II,III,IV	+0.355	<.001	9	view →
LUSC	Male	II,III,IV	−3.446	<.001	8	view →
STAD	Male	II,III,IV	−2.850	<.001	8	view →
READ	All	All	−5.022	<.001	5	view →
BRCA	Female	All	−0.816	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SCNN1B–KIRC

Open the KIRC breakdown →