SCNN1A

Across TCGA cell cohorts, SCNN1A mutation is significantly associated with the mutation status of many other genes, with 2,042 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCNN1A-associated genes across cancer lineages are PALMD, MORC1, and PLCL1. Each is linked with SCNN1A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCNN1A-to-partner and partner-to-SCNN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PALMD grouped by SCNN1A-low versus SCNN1A-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNN1A→partner) and Y-score (partner→SCNN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PALMD →	+5.437	+5.437	.003	.003	1	4
BONE	MORC1 →	+5.437	+5.437	.003	.003	1	4
CNS	PLCL1 →	+6.044	+6.044	.001	.001	1	4
SOFT_TISSUE	CELSR2 →	+4.651	+5.307	<.001	<.001	1	4
BLOOD_Lymphoma	ITGA5 →	+4.584	+4.584	.007	.007	1	4
LUNG_NSCLC_LUAD	TBC1D8 →	+4.187	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,042 associations by consensus.

PALMD by SCNN1A expression — BONE

Explore this box plot interactively →