SCN1A and SCN9A antisense RNA 1Genealiases: SCN1A-NAT · SCN1ANAT
Q-omics provides the consensus-scored SCN1A-AS1 profile across patient tissues and cancer cell-line models. SCN1A-AS1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SCN1A-AS1 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, SCN1A-AS1 RNA expression shows 11,436 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, KIRC, and TGCT as cancer lineages where SCN1A-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCN1A-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCN1A-AS1 survival associations across molecular data types. SCN1A-AS1 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCN1A-AS1 RNA expression–survival associations across cancer types. High SCN1A-AS1 expression shows unfavorable associations in KIRP, THCA, DLBC and MESO, but favorable associations in KIRC and ESCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SCN1A-AS1 RNA expression.
This table summarizes SCN1A-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for SCN1A-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCN1A-AS1 shows lower tumor expression in LUAD, LUSC, STAD and THCA and higher tumor expression in KIRC and HNSC. The KIRC box plot shows higher SCN1A-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.426, t-test p < 0.001).
This table shows molecular features associated with SCN1A-AS1 in patient tissues and cancer cell lines. In patient samples, SCN1A-AS1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
