SCN1A-AS1

Across TCGA pan-cancer cohorts, SCN1A-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SCN1A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCN1A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCN1A-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where SCN1A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCN1A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.426	<.001	11	view →
HNSC	Male	All	+0.225	<.001	8	view →
LUAD	Male	III,IV	−0.418	<.001	7	view →
LUSC	Male	II,III,IV	−0.268	<.001	6	view →
STAD	All	II,III,IV	−0.068	.003	6	view →
THCA	All	All	−0.091	.001	5	view →
BRCA	All	III,IV	−0.103	.001	4	view →
KICH	Male	III,IV	−0.170	<.001	3	view →
PRAD	All	All	−0.100	.001	2	view →
LIHC	All	All	+0.086	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SCN1A-AS1–KIRC

Open the KIRC breakdown →