SCN1A-AS1

Across TCGA pan-cancer cohorts, SCN1A-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SCN1A-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SCN1A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SCN1A-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

KIRP, KIRC, and THCA are the cancer types where SCN1A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.494	0.812	<.001	134	view →
KIRC	DFS	Quartile	II,III,IV	0.880	0.688	.002	64	view →
THCA	OS	Median	IV	0.547	0.939	<.001	32	view →
ESCA	OS	Median	All	0.778	0.628	.012	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
MESO	OS	Quartile	II,III,IV	0.269	0.485	.008	24	view →
CESC	OS	Quartile	IV	0.430	0.804	.008	22	view →
OV	OS	Quartile	All	0.909	0.815	.009	18	view →
ACC	OS	Quartile	All	0.239	0.762	.018	18	view →
HNSC	OS	Median	All	0.629	0.784	.005	11	view →
STAD	DFS	Median	IV	0.321	0.458	.010	9	view →
LIHC	OS	Tertile	III,IV	0.720	0.384	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SCN1A-AS1–KIRP (OS)

Open the KIRP breakdown →