SARS1

Across TCGA cell cohorts, SARS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SARS1-associated genes across cancer lineages are OR11H6, VN1R4, and ACER1. Each is linked with SARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SARS1-to-partner and partner-to-SARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by SARS1-low versus SARS1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARS1→partner) and Y-score (partner→SARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.025	+5.321	<.001	.005	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LARGE_INTESTINE	ACER1 →	+0.096	+3.823	.001	.006	3	1
BLOOD_Leukemia	ODF4 →	+0.047	+5.507	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR11H6 by SARS1 expression — CNS

Explore this box plot interactively →