SARS1

Across TCGA pan-cancer cohorts, SARS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SARS1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SARS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SARS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and GBM show a favorable association.

HNSC, BLCA, and KICH are the cancer types where SARS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.694	0.805	<.001	114	view →
BLCA	DFS	Tertile	All	0.510	0.668	<.001	102	view →
KICH	DFS	Tertile	III,IV	0.160	0.931	<.001	74	view →
ACC	DFS	Tertile	All	0.160	0.681	<.001	65	view →
LIHC	OS	Median	All	0.604	0.769	<.001	64	view →
LUSC	OS	Tertile	All	0.723	0.831	.001	58	view →
KIRC	OS	Tertile	All	0.734	0.559	<.001	40	view →
LAML	DFS	Quartile	All	0.319	0.638	<.001	36	view →
GBM	DFS	Quartile	All	0.348	0.176	.001	30	view →
READ	DFS	Quartile	All	0.924	0.718	.008	25	view →
MESO	DFS	Quartile	All	0.238	0.489	.010	23	view →
LGG	DFS	Quartile	All	0.710	0.861	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SARS1–HNSC (OS)

Open the HNSC breakdown →