SARS1

Across TCGA pan-cancer cohorts, SARS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SARS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SARS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SARS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where SARS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SARS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.433	<.001	9	view →
LIHC	Female	II,III,IV	+1.008	<.001	8	view →
KIRC	All	All	+0.295	<.001	8	view →
KICH	Female	II,III,IV	−1.082	<.001	5	view →
HNSC	Male	All	+0.265	.009	4	view →
CHOL	All	All	+1.311	<.001	3	view →
STAD	Male	II,III,IV	+0.596	.001	3	view →
UCEC	All	All	−0.480	.010	2	view →
LUSC	Female	All	−0.469	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SARS1–COAD

Open the COAD breakdown →