SALL4

Across TCGA cell cohorts, SALL4 mutation is significantly associated with the RNA expression of many other genes, with 1,430 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SALL4-associated genes across cancer lineages are C12orf40, FAM149A, and UTP3. Each is linked with SALL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SALL4-to-partner and partner-to-SALL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by SALL4-low versus SALL4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL4→partner) and Y-score (partner→SALL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
LARGE_INTESTINE	FAM149A →	+1.273	+2.389	<.001	.006	3	2
BLOOD_Leukemia	UTP3 →	+0.420	+3.199	.007	.007	3	2
BLOOD_Leukemia	MFSD4A →	+0.685	+3.199	.002	.007	3	2
BLOOD_Leukemia	ACBD7 →	+1.801	+3.199	<.001	.007	3	2
BLOOD_Leukemia	SATL1 →	+0.243	+3.498	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,430 associations by consensus.

C12orf40 by SALL4 expression — OVARY

Explore this box plot interactively →