SALL4

Across TCGA pan-cancer cohorts, SALL4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SALL4 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SALL4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SALL4 expression acts as an unfavorable survival marker, although some lineages such as THYM and BRCA show a favorable association.

KIRC, KIRP, and MESO are the cancer types where SALL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.532	0.706	<.001	130	view →
KIRP	OS	Median	All	0.603	0.764	<.001	97	view →
MESO	DFS	Tertile	All	0.262	0.459	.004	61	view →
THCA	OS	Quartile	All	0.939	1.000	<.001	60	view →
STAD	OS	Tertile	II,III,IV	0.411	0.717	.001	45	view →
UCEC	OS	Tertile	All	0.820	0.922	.001	32	view →
LGG	OS	Tertile	All	0.828	0.936	<.001	26	view →
CESC	DFS	Quartile	All	0.765	0.904	.001	22	view →
READ	DFS	Quartile	II,III,IV	0.428	0.809	.002	18	view →
THYM	DFS	Median	All	0.868	0.614	.007	18	view →
UVM	OS	Quartile	III,IV	0.322	0.898	.029	14	view →
BRCA	DFS	Quartile	IV	0.761	0.187	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SALL4–KIRC (DFS)

Open the KIRC breakdown →