Q-omics provides the consensus-scored SAGE3P profile across patient tissues and cancer cell-line models. SAGE3P expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in LUAD. Additionally, SAGE3P RNA expression shows 5,082 significant gene co-expression associations, with the highest sampling consensus in KIRC. Together, these results highlight LUAD, and KIRC as cancer lineages where SAGE3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes SAGE3P survival associations across molecular data types. SAGE3P RNA expression shows survival associations in the most cancer types (12), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

SAGE3P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	12	LUAD (129)	view →
Mutation	Kaplan–Meier	1	BRCA (24)	view →

This table ranks reproducible SAGE3P RNA expression–survival associations across cancer types. High SAGE3P expression shows unfavorable associations in LUAD, MESO, GBM, BLCA, LUSC and ESCA. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for SAGE3P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.166	0.756	<.001	129	view →
MESO	DFS	Tertile	III,IV	0.082	0.414	.007	54	view →
GBM	OS	Tertile	All	0.151	0.418	.001	36	view →
BLCA	OS	Tertile	IV	0.051	0.600	<.001	18	view →
LUSC	OS	Tertile	III,IV	0.227	0.575	.031	18	view →
ESCA	DFS	Tertile	II,III,IV	0.162	0.532	<.001	18	view →

Pink = unfavorable, green = favorable. all 12 lineages →

SAGE3P-LUAD (OS)

Kaplan–Meier survival curve for SAGE3P RNA expression in LUAD: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with SAGE3P in patient tissues and cancer cell lines. In patient samples, SAGE3P shows the broadest associations at the RNA and protein expression levels, with KIRC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	5,082	KIRC (1317)	view →
Function (RNA)	4,648	STAD (4192)	view →