SAGE3P

Across TCGA pan-cancer cohorts, SAGE3P RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SAGE3P data layer compared with 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SAGE3P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SAGE3P expression acts as an unfavorable survival marker, although some lineages such as UCS show a favorable association.

LUAD, MESO, and GBM are the cancer types where SAGE3P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.166	0.756	<.001	129	view →
MESO	DFS	Tertile	III,IV	0.082	0.414	.007	54	view →
GBM	OS	Tertile	All	0.151	0.418	.001	36	view →
BLCA	OS	Tertile	IV	0.051	0.600	<.001	18	view →
OV	OS	Tertile	IV	0.249	0.632	.044	18	view →
LUSC	OS	Tertile	III,IV	0.227	0.575	.031	18	view →
LAML	DFS	Tertile	All	0.193	0.588	.024	18	view →
ESCA	DFS	Tertile	II,III,IV	0.162	0.532	<.001	18	view →
UCS	DFS	Tertile	II,III,IV	0.674	0.346	.026	12	view →
THYM	DFS	Tertile	All	0.174	0.813	.029	9	view →
THCA	DFS	Tertile	III,IV	0.114	0.740	.001	9	view →
COAD	OS	Tertile	II,III,IV	0.532	0.853	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SAGE3P–LUAD (OS)

Open the LUAD breakdown →