S100Z

Across TCGA patient cohorts, S100Z mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible S100Z-associated genes across cancer lineages are ARL2BPP4, RNA5SP335, and RPL12P34. Each is linked with S100Z in more than 1 cancer types. Because this analysis shows association rather than direction, both S100Z-to-partner and partner-to-S100Z results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL2BPP4 grouped by S100Z-low versus S100Z-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100Z→partner) and Y-score (partner→S100Z) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARL2BPP4 →	+0.253	+3.224	<.001	.001	3	2
COAD	RNA5SP335 →	+0.841	+5.435	.001	.005	3	1
COAD	RPL12P34 →	+0.377	+5.145	.001	.007	3	1
COAD	UBL5P1 →	+0.581	+5.283	<.001	.006	3	1
COAD	SLC20A1P3 →	+0.162	+6.917	<.001	<.001	3	1
COAD	YWHAQP1 →	+0.287	+5.435	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

ARL2BPP4 by S100Z expression — UCEC

Explore this box plot interactively →