S100Z

Across TCGA pan-cancer cohorts, S100Z RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated S100Z data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher S100Z RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated S100Z expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

STAD, HNSC, and LGG are the cancer types where S100Z RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.541	0.816	.002	76	view →
HNSC	DFS	Median	III,IV	0.684	0.505	<.001	67	view →
LGG	DFS	Median	All	0.269	0.499	<.001	49	view →
SKCM	OS	Median	II,III,IV	0.404	0.205	<.001	48	view →
PAAD	DFS	Tertile	All	0.411	0.193	<.001	45	view →
ESCA	DFS	Quartile	All	0.498	0.225	.011	27	view →
COAD	OS	Median	IV	0.876	0.409	.004	17	view →
UCEC	OS	Quartile	All	0.812	0.900	.012	14	view →
KIRC	DFS	Median	IV	0.765	0.394	.003	12	view →
CHOL	DFS	Median	All	0.596	0.200	.018	12	view →
BLCA	DFS	Quartile	IV	0.141	0.349	.010	10	view →
UVM	DFS	Quartile	II,III,IV	0.292	0.607	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

S100Z–STAD (DFS)

Open the STAD breakdown →