S100Z

Across TCGA pan-cancer cohorts, S100Z RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of S100Z’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where S100Z RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100Z is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, LUSC, and THCA are the cancer types where S100Z tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100Z RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.469	<.001	12	view →
LUSC	Female	All	−0.432	<.001	9	view →
THCA	Male	II,III,IV	+0.257	.001	7	view →
COAD	All	All	−0.120	.001	4	view →
KICH	All	II,III,IV	−0.107	.034	3	view →
HNSC	Female	II,III,IV	+0.085	.026	3	view →
KIRP	All	All	+0.183	.004	2	view →
CHOL	All	All	+0.152	.033	1	view →
LIHC	All	All	+0.034	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

S100Z–KIRC

Open the KIRC breakdown →