S100A7

Across TCGA patient cohorts, S100A7 mutation is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100A7-associated genes across cancer lineages are VN1R93P, RNU6-730P, and RNU6-151P. Each is linked with S100A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both S100A7-to-partner and partner-to-S100A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R93P grouped by S100A7-low versus S100A7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A7→partner) and Y-score (partner→S100A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VN1R93P →	+0.159	+5.015	<.001	.009	3	3
SKCM	RNU6-730P →	+0.232	+4.385	<.001	.008	3	2
LUAD	RNU6-151P →	+0.638	+4.110	.009	.002	3	2
LUAD	MDH1P2 →	+0.045	+4.279	<.001	.001	3	2
LUAD	LRRC57P1 →	+0.065	+3.613	.007	.006	3	2
LUAD	RNU6-988P →	+0.768	+3.600	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

VN1R93P by S100A7 expression — HNSC

Explore this box plot interactively →