S100A7

Across TCGA pan-cancer cohorts, S100A7 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of S100A7’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where S100A7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100A7 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUSC, BRCA, and LUAD are the cancer types where S100A7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	+5.570	<.001	8	view →
BRCA	Female	II,III,IV	+2.046	<.001	6	view →
LUAD	All	All	+0.933	<.001	6	view →
BLCA	Male	All	+4.554	.004	4	view →
COAD	All	All	+0.352	.002	4	view →
KICH	All	All	−0.192	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

S100A7–LUSC

Open the LUSC breakdown →