S100A7

Across TCGA pan-cancer cohorts, S100A7 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated S100A7 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher S100A7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated S100A7 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

KIRC, COAD, and KIRP are the cancer types where S100A7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.524	0.695	<.001	105	view →
COAD	OS	Tertile	All	0.797	0.944	<.001	72	view →
KIRP	DFS	Quartile	All	0.436	0.750	<.001	48	view →
BLCA	OS	Tertile	All	0.350	0.521	.008	41	view →
SKCM	OS	Median	All	0.682	0.868	<.001	36	view →
BRCA	DFS	Tertile	III,IV	0.789	0.931	.010	27	view →
ACC	DFS	Quartile	II,III,IV	0.155	0.600	<.001	24	view →
READ	OS	Median	II,III,IV	0.311	0.752	.006	23	view →
LAML	DFS	Tertile	All	0.172	0.433	.014	18	view →
ESCA	DFS	Quartile	III,IV	0.574	0.281	.007	15	view →
LIHC	OS	Quartile	All	0.413	0.552	.019	15	view →
HNSC	OS	Tertile	All	0.599	0.249	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

S100A7–KIRC (DFS)

Open the KIRC breakdown →