RS1

Across TCGA patient cohorts, RS1 mutation is significantly associated with the RNA expression of many other genes, with 2,099 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RS1-associated genes across cancer lineages are MIR7976, MIR548AY, and SLCO1B1. Each is linked with RS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RS1-to-partner and partner-to-RS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7976 grouped by RS1-low versus RS1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RS1→partner) and Y-score (partner→RS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR7976 →	+0.437	+3.269	.009	.008	3	2
HNSC	MIR548AY →	+0.440	+3.748	<.001	.008	3	2
SKCM	SLCO1B1 →	+0.716	+3.745	<.001	.004	3	2
CESC	TRAJ30 →	+0.366	+4.103	<.001	.002	3	2
UCEC	ARPP19P2 →	+0.181	+2.064	.002	.002	3	2
UCEC	PINCR →	+0.198	+1.966	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,099 associations by consensus.

MIR7976 by RS1 expression — CESC

Explore this box plot interactively →