RS1

Across TCGA pan-cancer cohorts, RS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RS1 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, KIRC, and THCA are the cancer types where RS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−2.516	<.001	11	view →
KIRC	Male	II,III,IV	−0.328	<.001	11	view →
THCA	Female	II,III,IV	−0.631	<.001	10	view →
LUSC	Female	All	−2.362	<.001	9	view →
KICH	Male	All	−0.661	<.001	7	view →
LIHC	All	All	+0.036	.001	7	view →
KIRP	Male	All	−0.257	<.001	6	view →
BRCA	All	III,IV	−0.068	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RS1–LUAD

Open the LUAD breakdown →