RPSA

Across TCGA patient cohorts, RPSA mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible RPSA-associated genes across cancer lineages are RNA5SP176, RNU6-1180P, and MIR320B1. Each is linked with RPSA in more than 2 cancer types. Because this analysis shows association rather than direction, both RPSA-to-partner and partner-to-RPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP176 grouped by RPSA-low versus RPSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPSA→partner) and Y-score (partner→RPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP176 →	+0.432	+4.437	<.001	.005	3	3
UCEC	RNU6-1180P →	+0.217	+4.069	<.001	.008	3	2
SKCM	MIR320B1 →	+0.517	+4.875	<.001	.002	3	2
SKCM	ZNF25-DT →	+0.129	+5.208	<.001	.001	3	2
LUAD	DCAF4L2 →	+0.894	+3.857	.007	.008	3	1
LUAD	LINC01551 →	+0.471	+3.945	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

RNA5SP176 by RPSA expression — UCEC

Explore this box plot interactively →