RPSA

Across TCGA pan-cancer cohorts, RPSA RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPSA’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RPSA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPSA is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

LIHC, KIRP, and KIRC are the cancer types where RPSA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPSA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.695	<.001	9	view →
KIRP	All	II,III,IV	+0.906	<.001	9	view →
KIRC	All	All	+0.322	<.001	9	view →
COAD	Female	II,III,IV	+0.824	<.001	8	view →
CHOL	Male	All	+2.265	<.001	5	view →
HNSC	Female	II,III,IV	−0.591	.007	5	view →
STAD	All	II,III,IV	+0.397	.013	4	view →
BLCA	Male	All	+0.514	.020	3	view →
BRCA	All	IV	−0.834	.022	2	view →
LUSC	Male	All	+0.319	.009	2	view →
PRAD	All	All	+0.252	.020	2	view →
READ	All	All	+0.523	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPSA–LIHC

Open the LIHC breakdown →