RPSA

Across TCGA pan-cancer cohorts, RPSA RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RPSA data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RPSA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RPSA expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, LIHC, and ACC are the cancer types where RPSA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.770	0.401	<.001	103	view →
LIHC	DFS	Median	All	0.466	0.615	<.001	91	view →
ACC	DFS	Median	All	0.254	0.619	<.001	81	view →
KIRC	OS	Quartile	All	0.750	0.932	<.001	81	view →
KICH	DFS	Quartile	II,III,IV	0.250	1.000	.002	77	view →
BRCA	OS	Tertile	II,III,IV	0.926	0.875	.011	39	view →
LGG	DFS	Median	All	0.811	0.656	<.001	36	view →
THYM	OS	Tertile	All	1.000	0.881	.011	27	view →
SCLC	OS	Median	IV	0.233	0.718	.015	22	view →
LUAD	DFS	Quartile	III,IV	0.338	0.626	.013	19	view →
PAAD	DFS	Quartile	All	0.222	0.398	.004	17	view →
DLBC	OS	Median	IV	0.417	1.000	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RPSA–UVM (DFS)

Open the UVM breakdown →