RNA, U6 small nuclear 375, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-375P profile across patient tissues and cancer cell-line models. RNU6-375P expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RNU6-375P is differentially expressed in 5, with the highest sampling consensus in KIRC. Additionally, RNU6-375P RNA expression shows 6,679 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight KIRC, and LAML as cancer lineages where RNU6-375P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-375P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-375P survival associations across molecular data types. RNU6-375P RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-375P RNA expression–survival associations across cancer types. High RNU6-375P expression shows unfavorable associations in KIRC, OV, HNSC and ACC, but favorable associations in BRCA and ESCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for RNU6-375P RNA expression.
This table summarizes RNU6-375P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-375P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-375P shows lower tumor expression in LUAD, KIRP and THCA and higher tumor expression in KIRC and CHOL. The KIRC box plot shows higher RNU6-375P RNA expression in tumor versus normal tissue (log2 FC = +0.193, t-test p = .009).
This table shows molecular features associated with RNU6-375P in patient tissues and cancer cell lines. In patient samples, RNU6-375P shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set.
