RNF6

Across TCGA cell cohorts, RNF6 mutation is significantly associated with the mutation status of many other genes, with 2,500 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF6-associated genes across cancer lineages are SLC6A11, HTR1B, and LPA. Each is linked with RNF6 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF6-to-partner and partner-to-RNF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A11 grouped by RNF6-low versus RNF6-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF6→partner) and Y-score (partner→RNF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC6A11 →	+4.807	+4.807	.008	.008	1	4
STOMACH	HTR1B →	+4.807	+4.807	.008	.008	1	4
LUNG_NSCLC_LUAD	LPA →	+2.548	+3.469	.004	.004	1	4
BLOOD_Lymphoma	DMTF1 →	+4.169	+5.316	<.001	<.001	1	4
BLOOD_Lymphoma	MYPN →	+3.584	+4.922	.001	.001	1	4
STOMACH	SIDT2 →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,500 associations by consensus.

SLC6A11 by RNF6 expression — STOMACH

Explore this box plot interactively →