RNF6

Across TCGA pan-cancer cohorts, RNF6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RNF6’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where RNF6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

STAD, BLCA, and LIHC are the cancer types where RNF6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.912	<.001	8	view →
BLCA	Male	All	+0.815	<.001	8	view →
LIHC	Male	All	+0.647	<.001	8	view →
HNSC	All	All	+0.569	<.001	8	view →
THCA	All	All	−0.421	<.001	7	view →
KICH	All	All	−0.568	<.001	6	view →
COAD	Male	II,III,IV	+0.607	<.001	5	view →
LUAD	All	III,IV	−0.443	.009	5	view →
CHOL	All	All	+1.196	.001	4	view →
BRCA	All	All	+0.199	.002	4	view →
KIRC	All	All	+0.191	.011	3	view →
PAAD	Male	All	+0.395	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RNF6–STAD

Open the STAD breakdown →