RNF6

Across TCGA pan-cancer cohorts, RNF6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RNF6 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher RNF6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

CESC, KIRC, and ESCA are the cancer types where RNF6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.406	0.660	<.001	100	view →
KIRC	DFS	Median	All	0.875	0.714	<.001	84	view →
ESCA	DFS	Median	All	0.221	0.403	.014	36	view →
UCEC	DFS	Median	III,IV	0.696	0.454	.010	24	view →
UVM	DFS	Quartile	III,IV	0.133	0.814	<.001	23	view →
HNSC	OS	Quartile	IV	0.292	0.649	.005	16	view →
OV	DFS	Tertile	IV	0.340	0.574	.033	16	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	15	view →
STAD	OS	Quartile	All	0.622	0.420	.003	14	view →
DLBC	DFS	Tertile	All	0.683	1.000	.008	14	view →
COAD	DFS	Quartile	II,III,IV	0.683	0.833	.006	13	view →
LGG	OS	Tertile	All	0.745	0.894	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RNF6–CESC (DFS)

Open the CESC breakdown →