RNF41

Across TCGA patient cohorts, RNF41 mutation is significantly associated with the RNA expression of many other genes, with 3,608 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF41-associated genes across cancer lineages are CLDN7P1, RN7SL393P, and HSPE1P10. Each is linked with RNF41 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF41-to-partner and partner-to-RNF41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN7P1 grouped by RNF41-low versus RNF41-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF41→partner) and Y-score (partner→RNF41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLDN7P1 →	+0.044	+4.797	.007	.003	3	2
COAD	RN7SL393P →	+0.185	+4.070	.004	.009	3	2
COAD	HSPE1P10 →	+0.267	+4.040	<.001	.001	3	2
CESC	MICG →	+0.284	+5.554	<.001	<.001	3	1
CESC	RN7SL681P →	+0.127	+3.934	<.001	.005	3	1
CESC	MTND5P5 →	+0.063	+4.559	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,608 associations by consensus.

CLDN7P1 by RNF41 expression — BRCA

Explore this box plot interactively →