RNF41

Across TCGA pan-cancer cohorts, RNF41 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF41’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RNF41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF41 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where RNF41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.662	<.001	10	view →
LIHC	Female	II,III,IV	+0.939	<.001	8	view →
KICH	Female	All	−1.001	<.001	7	view →
LUAD	Female	II,III,IV	−0.542	<.001	7	view →
THCA	All	All	−0.244	.005	7	view →
HNSC	All	All	+0.355	<.001	6	view →
LUSC	All	All	−0.294	<.001	6	view →
BRCA	Female	All	−0.187	<.001	4	view →
CHOL	Male	All	+1.796	<.001	3	view →
STAD	All	II,III,IV	+0.460	.010	3	view →
ESCA	All	All	+0.601	.008	2	view →
PRAD	All	All	+0.507	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF41–COAD

Open the COAD breakdown →