RNF41

Across TCGA pan-cancer cohorts, RNF41 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RNF41 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RNF41 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF41 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, MESO, and ACC are the cancer types where RNF41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.715	0.539	<.001	88	view →
MESO	OS	Median	All	0.295	0.477	.004	76	view →
ACC	DFS	Tertile	All	0.292	0.739	<.001	63	view →
BLCA	DFS	Tertile	All	0.227	0.616	.001	51	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	41	view →
HNSC	OS	Median	All	0.317	0.493	.002	36	view →
LIHC	DFS	Tertile	All	0.421	0.578	.002	32	view →
UVM	DFS	Tertile	All	0.307	0.665	.001	30	view →
CESC	DFS	Tertile	III,IV	0.478	0.852	.006	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LAML	DFS	Median	All	0.482	0.644	.010	20	view →
LGG	DFS	Tertile	All	0.891	0.757	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RNF41–KIRC (DFS)

Open the KIRC breakdown →