RNASEH2A

Across TCGA patient cohorts, RNASEH2A protein abundance is significantly associated with the RNA expression of many other genes, with 14,444 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RNASEH2A-associated genes across cancer lineages are RNASEH2B, BRCA2, and FANCD2. Each is linked with RNASEH2A in more than 9 cancer types. Because this analysis shows association rather than direction, both RNASEH2A-to-partner and partner-to-RNASEH2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNASEH2A versus RNASEH2B in HNSC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2A→partner) and Y-score (partner→RNASEH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNASEH2B →	+0.530	+0.300	<.001	<.001	3	10
UCEC	BRCA2 →	+0.664	+0.325	<.001	<.001	3	8
HNSC	FANCD2 →	+0.789	+0.367	<.001	<.001	3	7
HNSC	SUGT1-DT →	+0.676	+0.416	<.001	<.001	3	7
OV	RBL1 →	+0.905	+0.349	<.001	<.001	3	7
LSCC	NUFIP1 →	+0.590	+0.281	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,444 associations by consensus.

RNASEH2A vs RNASEH2B — HNSC

Explore this scatter interactively →