RNASEH2A

Across TCGA pan-cancer cohorts, RNASEH2A RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of RNASEH2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNASEH2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASEH2A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where RNASEH2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASEH2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.853	<.001	12	view →
KIRC	Male	IV	+1.037	<.001	12	view →
COAD	Female	III,IV	+2.171	<.001	11	view →
BLCA	Male	All	+1.882	<.001	11	view →
KIRP	All	III,IV	+1.682	<.001	11	view →
LUAD	All	III,IV	+1.324	<.001	11	view →
LIHC	Male	All	+2.073	<.001	9	view →
STAD	All	III,IV	+1.833	<.001	9	view →
LUSC	Female	All	+2.363	<.001	8	view →
READ	All	All	+1.330	<.001	7	view →
UCEC	All	III,IV	+1.847	<.001	6	view →
BRCA	All	III,IV	+1.696	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

RNASEH2A–HNSC

Open the HNSC breakdown →