RNASEH2A

Across TCGA pan-cancer cohorts, RNASEH2A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RNASEH2A data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNASEH2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNASEH2A expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

ACC, MESO, and KICH are the cancer types where RNASEH2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.358	0.793	<.001	143	view →
MESO	OS	Median	All	0.417	0.669	<.001	108	view →
KICH	DFS	Tertile	All	0.620	1.000	.001	99	view →
KIRP	DFS	Median	All	0.847	0.966	<.001	87	view →
LIHC	DFS	Median	All	0.462	0.623	<.001	76	view →
CESC	DFS	Median	All	0.806	0.668	.003	64	view →
LGG	OS	Median	All	0.368	0.523	<.001	49	view →
SARC	DFS	Median	All	0.539	0.679	<.001	34	view →
LUSC	DFS	Tertile	All	0.468	0.292	.001	32	view →
SCLC	DFS	Tertile	II,III,IV	0.580	0.161	.006	29	view →
BLCA	DFS	Median	IV	0.305	0.605	.012	25	view →
PAAD	OS	Median	All	0.533	0.685	.010	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RNASEH2A–ACC (DFS)

Open the ACC breakdown →