RIMKLA

Across TCGA patient cohorts, RIMKLA mutation is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIMKLA-associated genes across cancer lineages are NTAN1, MED27, and TALDO1. Each is linked with RIMKLA in more than 1 cancer types. Because this analysis shows association rather than direction, both RIMKLA-to-partner and partner-to-RIMKLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTAN1 grouped by RIMKLA-low versus RIMKLA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMKLA→partner) and Y-score (partner→RIMKLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NTAN1 →	+0.450	+3.732	.002	<.001	3	2
UCEC	MED27 →	+0.319	+2.487	.007	.001	3	2
UCEC	TALDO1 →	+0.427	+2.403	.006	<.001	3	2
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	2
COAD	MT-TN →	+0.388	+5.003	<.001	.004	3	2
LUAD	OR1AC1P →	+1.124	+5.044	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

NTAN1 by RIMKLA expression — SKCM

Explore this box plot interactively →