RIMKLA

Across TCGA pan-cancer cohorts, RIMKLA RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RIMKLA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RIMKLA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIMKLA is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where RIMKLA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIMKLA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.975	<.001	12	view →
KIRP	All	II,III,IV	+1.636	<.001	11	view →
THCA	Male	III,IV	−1.360	<.001	11	view →
KICH	Male	IV	−1.256	<.001	10	view →
COAD	All	III,IV	−1.123	<.001	10	view →
LUSC	All	III,IV	−1.673	<.001	9	view →
LUAD	Female	III,IV	−1.674	<.001	8	view →
UCEC	All	II,III,IV	+2.017	<.001	6	view →
BRCA	All	III,IV	+1.135	<.001	6	view →
READ	All	All	−1.458	<.001	5	view →
CHOL	All	All	+1.181	<.001	3	view →
LIHC	All	All	+0.253	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RIMKLA–KIRC

Open the KIRC breakdown →