RGS2

Across TCGA patient cohorts, RGS2 mutation is significantly associated with the RNA expression of many other genes, with 1,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS2-associated genes across cancer lineages are RNU6-709P, RNU6ATAC29P, and RNU6-158P. Each is linked with RGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS2-to-partner and partner-to-RGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by RGS2-low versus RGS2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS2→partner) and Y-score (partner→RGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-709P →	+0.225	+6.174	<.001	<.001	3	2
LUAD	RNU6ATAC29P →	+0.380	+5.157	.004	.007	3	2
UCEC	RNU6-158P →	+0.312	+2.640	<.001	.003	3	2
LUAD	RNU6-1114P →	+0.457	+5.798	<.001	.003	3	2
LUSC	RNU6-223P →	+0.443	+5.404	<.001	.005	3	1
UCEC	CCDC15 →	+0.484	+3.338	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,035 associations by consensus.

RNU6-709P by RGS2 expression — CESC

Explore this box plot interactively →