RGS2

Across TCGA pan-cancer cohorts, RGS2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RGS2 data layer compared with 4 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RGS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RGS2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

STAD, UCS, and KIRP are the cancer types where RGS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.608	0.835	.001	76	view →
UCS	DFS	Tertile	All	0.678	0.274	.002	74	view →
KIRP	DFS	Quartile	III,IV	0.560	0.868	.007	63	view →
BLCA	OS	Tertile	All	0.552	0.715	.001	47	view →
COAD	DFS	Median	III,IV	0.248	0.652	.002	38	view →
SKCM	OS	Median	All	0.405	0.246	<.001	33	view →
THCA	OS	Median	II,III,IV	0.825	1.000	.011	23	view →
KIRC	DFS	Median	All	0.569	0.677	.004	20	view →
LIHC	OS	Tertile	All	0.441	0.601	.007	19	view →
READ	DFS	Median	III,IV	0.412	0.801	.002	18	view →
OV	DFS	Median	III,IV	0.332	0.408	.017	16	view →
THYM	DFS	Quartile	III,IV	0.690	1.000	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RGS2–STAD (OS)

Open the STAD breakdown →