RGS2

Across TCGA pan-cancer cohorts, RGS2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RGS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RGS2 RNA is repressed in tumor relative to normal tissue. In most cancer types RGS2 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and UCEC are the cancer types where RGS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−3.867	<.001	11	view →
BLCA	Male	III,IV	−3.094	<.001	11	view →
UCEC	All	All	−3.831	<.001	8	view →
BRCA	All	III,IV	−2.506	<.001	8	view →
COAD	Female	II,III,IV	−1.482	<.001	8	view →
STAD	All	All	−1.506	<.001	7	view →
KIRC	All	II,III,IV	−0.839	<.001	7	view →
LUSC	Male	II,III,IV	−1.925	<.001	6	view →
THCA	Female	All	−1.464	<.001	6	view →
LUAD	All	II,III,IV	−0.979	<.001	6	view →
KIRP	All	All	−1.152	<.001	5	view →
READ	Female	All	−2.454	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RGS2–KICH

Open the KICH breakdown →