RGN

Across TCGA patient cohorts, RGN protein abundance is significantly associated with the RNA expression of many other genes, with 19,619 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RGN-associated genes across cancer lineages are SCN7A, MYL3, and MYOM1. Each is linked with RGN in more than 6 cancer types. Because this analysis shows association rather than direction, both RGN-to-partner and partner-to-RGN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RGN versus SCN7A in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGN→partner) and Y-score (partner→RGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCN7A →	+1.351	+0.640	<.001	<.001	3	7
HNSC	MYL3 →	+1.009	+0.456	.001	<.001	3	7
HNSC	MYOM1 →	+0.976	+0.401	<.001	<.001	3	6
CCRCC	ASPA →	+1.226	+0.544	<.001	<.001	3	6
LUAD	HLF →	+1.176	+0.528	<.001	<.001	3	6
LUAD	NCAPG →	-1.171	-0.656	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,619 associations by consensus.

RGN vs SCN7A — LSCC

Explore this scatter interactively →