RGN

Across TCGA pan-cancer cohorts, RGN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RGN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RGN RNA is repressed in tumor relative to normal tissue. In most cancer types RGN is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BLCA are the cancer types where RGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.193	<.001	12	view →
KIRP	All	III,IV	−2.411	<.001	11	view →
BLCA	All	IV	−2.320	<.001	11	view →
HNSC	Male	All	−1.146	<.001	11	view →
LUSC	Female	II,III,IV	−3.025	<.001	9	view →
LUAD	All	III,IV	−1.560	<.001	9	view →
THCA	All	III,IV	−1.128	<.001	9	view →
STAD	All	III,IV	−1.791	<.001	8	view →
KICH	All	II,III,IV	−1.762	<.001	8	view →
UCEC	All	II,III,IV	−2.563	<.001	6	view →
BRCA	All	III,IV	−2.290	<.001	6	view →
LIHC	All	All	−0.761	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RGN–KIRC

Open the KIRC breakdown →