RGN

Across TCGA pan-cancer cohorts, RGN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RGN data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RGN RNA is associated with better overall survival. In most high-consensus cancer types, elevated RGN expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

LUAD, KIRC, and LIHC are the cancer types where RGN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.867	0.740	<.001	103	view →
KIRC	OS	Tertile	All	0.700	0.526	<.001	68	view →
LIHC	OS	Median	All	0.699	0.444	<.001	63	view →
COAD	DFS	Median	III,IV	0.445	0.769	<.001	51	view →
KIRP	OS	Quartile	All	0.963	0.782	<.001	51	view →
LGG	OS	Median	All	0.734	0.878	<.001	46	view →
UCS	DFS	Quartile	All	0.313	0.633	.024	42	view →
ACC	OS	Median	II,III,IV	0.870	0.644	.004	39	view →
LUSC	DFS	Median	All	0.317	0.447	.009	28	view →
HNSC	OS	Median	IV	0.510	0.309	.004	27	view →
UVM	DFS	Tertile	III,IV	0.155	0.718	.024	18	view →
GBM	DFS	Quartile	All	0.174	0.475	.005	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RGN–LUAD (OS)

Open the LUAD breakdown →