RGN

Across TCGA patient cohorts, RGN mutation is significantly associated with the RNA expression of many other genes, with 964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGN-associated genes across cancer lineages are RNU6-961P, FCER1A, and TMEM150B. Each is linked with RGN in more than 1 cancer types. Because this analysis shows association rather than direction, both RGN-to-partner and partner-to-RGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-961P grouped by RGN-low versus RGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGN→partner) and Y-score (partner→RGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-961P →	+0.084	+4.153	<.001	.005	3	2
UCEC	FCER1A →	-0.828	-2.906	.002	.002	3	1
UCEC	TMEM150B →	+0.591	+3.201	.003	.009	3	1
UCEC	CCDC43 →	+0.559	+3.354	.001	.005	3	1
UCEC	NQO1 →	+1.547	+2.625	<.001	.005	3	1
UCEC	MEX3D →	+0.700	+3.480	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 964 associations by consensus.

RNU6-961P by RGN expression — UCEC

Explore this box plot interactively →