RGN

Across TCGA patient cohorts, RGN mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGN-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with RGN in more than 1 cancer types. Because this analysis shows association rather than direction, both RGN-to-partner and partner-to-RGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by RGN-low versus RGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGN→partner) and Y-score (partner→RGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.377	-3.459	.007	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.195	-3.321	.007	.010	3	1
UCEC	p62 Lck ligand →	+0.388	+3.169	.006	.018	3	1
UCEC	Akt_pT308 →	+0.663	+2.459	.015	.019	3	1
UCEC	P-Cadherin →	-0.141	-2.999	.024	.035	3	1
UCEC	PCNA →	+0.208	+2.115	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

INPP4B by RGN expression — UCEC

Explore this box plot interactively →